Structure of PDB 6fa3 Chain A

Receptor sequence
>6fa3A (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVID
GETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYR
EQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAK
TRQGVDDAFYTLVREIRKHKE
3D structure
PDB6fa3 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D1Z A K5 L6 V7 S39 Y40 R41 D54 L56 Y71 T74 K8 L9 V10 S42 Y43 R44 D57 L59 Y74 T77 MOAD: Kd=0.038uM
BS02 MG A S17 T35 S20 T38
BS03 GNP A G13 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146 G16 G18 K19 S20 A21 F31 V32 D33 Y35 P37 T38 G63 N119 K120 D122 L123 S148 A149
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6fa3, PDBe:6fa3, PDBj:6fa3
PDBsum6fa3
PubMed30093669
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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