Structure of PDB 6f8r Chain A

Receptor sequence
>6f8rA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPV
DTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLE
ILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFK
LLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVET
KKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEE
FFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVH
PDAQDILDTLEDNREWYQSTIP
3D structure
PDB6f8r Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
ChainA
Resolution1.826 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CZK A Y325 H326 S374 I502 F506 M523 Q535 F538 Y70 H71 S119 I247 F251 M268 Q280 F283 MOAD: ic50=20uM
PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
BS02 MG A D467 D471 D212 D216
BS03 ZN A H330 H366 D367 D484 H75 H111 D112 D229
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6f8r, PDBe:6f8r, PDBj:6f8r
PDBsum6f8r
PubMed29652483
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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