Structure of PDB 6f7v Chain A

Receptor sequence

>6f7vA (length=430) Species: 885435 (Streptomyces rochei subsp. volubilis) [Search protein sequence]

VEAKSRIAVVGGGGSGSVAAWLLARRHDVTLFEADEYLGGHAYSHPVETD
QGTLHVDMGVQHFNEKLSPNLFRLLTDFGIGTYVAPSSVHVDFPGEQQSW
NNLDFLGELREELHEEFDRFHQEMNQLPTSKQMSIGEYLDKHGYSKSFKY
KAMNPILSIYSGCHAPSLDYNLMYVALSFSMNLLSFFSAGYWRKAQGGIH
SYLARIESDLGERVRLNTPVEAVVPTQSGVTVLAGGQEHHFDQVVFATHA
DVTLRLLRTSDQQYRDLLGDFAYVPVESVLHQDESWLSPAGGGAYCQFRM
PEGFELARAEEQMGSLTRNCNVLHPYRKVSSPILITFDPQEDVDPERVIV
RREWKLPQLRPVDVRRKKRLHEIQGLNGLWFCGTDTSVTGHEGAIVSGMV
IADRLGVPHPFPDDAPAAAQFRGIKEFMGV

3D structure

PDB

6f7v Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis.

Chain

Resolution

3.03 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.4.3.4: monoamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G14 G16 S18 E36 A37 G43 H44 G62 V63 Q64 H65 V228 T256 H257 W362 L364 G391 T392 G398 H399 A402	G11 G13 S15 E33 A34 G40 H41 G59 V60 Q61 H62 V220 T248 H249 W354 L356 G383 T384 G390 H391 A394
BS02	CWH	A	L70 I167 Y168 R326 F345 V396 T397 G398 Q428	L67 I159 Y160 R318 F337 V388 T389 G390 Q420

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6f7v, PDBe:6f7v, PDBj:6f7v
PDBsum	6f7v
PubMed	30266997
UniProt	G4V2H3

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