Structure of PDB 6f7i Chain A

Receptor sequence
>6f7iA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
QPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDL
TEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRS
ENCLCVQNILKLMQEKETGLNVFLLDMCRVTANIVFGYATCQSGLANGIF
MKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALT
DPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNV
MIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSK
DLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPL
IAKLD
3D structure
PDB6f7i An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CW5 A V344 A345 K379 V381 E390 N393 A394 E397 L401 Q579 W580 Q676 I712 L715 D716 V8 A9 K43 V45 E54 N57 A58 E61 L65 Q218 W219 Q315 I351 L354 D355 PDBbind-CN: -logKd/Ki=7.85,IC50=14nM
BS02 MG A K648 G649 E653 K287 G288 E292
BS03 MG A E652 Y657 S660 E291 Y296 S299
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6f7i, PDBe:6f7i, PDBj:6f7i
PDBsum6f7i
PubMed30692685
UniProtQ9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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