Structure of PDB 6f7h Chain A

Receptor sequence
>6f7hA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
SLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVT
IAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGA
TYVLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGT
GMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPAR
DLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALH
H
3D structure
PDB6f7h Human adipose glycerol flux is regulated by a pH gate in AQP10.
ChainA
Resolution2.304 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL A N82 N214 N65 N197
BS02 GOL A S63 M196 S46 M179
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015204 urea transmembrane transporter activity
GO:0015250 water channel activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
Biological Process
GO:0006833 water transport
GO:0009636 response to toxic substance
GO:0015791 polyol transmembrane transport
GO:0015793 glycerol transmembrane transport
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0071468 cellular response to acidic pH
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6f7h, PDBe:6f7h, PDBj:6f7h
PDBsum6f7h
PubMed30420639
UniProtQ96PS8|AQP10_HUMAN Aquaporin-10 (Gene Name=AQP10)

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