Structure of PDB 6f7b Chain A

Receptor sequence
>6f7bA (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
APNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQL
GSKLVYVHHLLGEGAFAQVYEATQKNKQKFVLKVQKPANPWEFYIGTQLM
ERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKV
MPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDL
SAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDY
FGVAATVYCMLFGTYMKVKNEECKPEGLFRRLPHLDMWNEFFHVMLNIPD
CHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRS
3D structure
PDB6f7b Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CVQ A V801 V819 K821 E830 G834 F849 M850 F852 L864 Y869 I924 I945 D946 L947 V69 V81 K83 E92 G96 F111 M112 F114 L126 Y131 I186 I207 D208 L209 PDBbind-CN: -logKd/Ki=8.89,Kd=1.3nM
BS02 MG A D917 D946 Q949 S969 D179 D208 Q211 S231
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007094 mitotic spindle assembly checkpoint signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:6f7b, PDBe:6f7b, PDBj:6f7b
PDBsum6f7b
PubMed30429199
UniProtO43683|BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (Gene Name=BUB1)

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