Structure of PDB 6f79 Chain A

Receptor sequence

>6f79A (length=323) Species: 2026 (Thermoactinomyces vulgaris)

DFPSYDSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKIS
DNVGTDENEPEVLYTALHHAREHLTVEMALYTLDLFTQNYNLDSRITNLV
NNREIYIVFNINPDGGEYDISSGSYKSWRKNRQPNSGSSYVGTDLNRNYG
YKWGCCGGSSGSPSSETYRGRSAFSAPETAAMRDFINSRVVGGKQQIKTL
ITFHTYSELIQYPYGYTYTDVPSDMTQDDFNVFKTMANTMAQTNGYTPQQ
ASDLYITDGDMTDWAYGQHKIFAFTFEMYPTSYNPGFYPPDEVIGRETSR
NKEAVLYVAEKADCPYSVIGKSC

3D structure

• PDB: 6f79 Carboxypeptidase T mutant L211Q with Sulphamoil Arginine
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H69 E72 R129 H204 E277
• Catalytic site (residue number reindexed from 1): H69 E72 R129 H204 E277
• Enzyme Commision number: 3.4.17.18: carboxypeptidase T.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H69 E72 H204	H69 E72 H204
BS02	CA	A	S7 Y9 E14	S7 Y9 E14
BS03	CA	A	S50 D51 E57 E59	S50 D51 E57 E59
BS04	CA	A	Y5 D291 E292	Y5 D291 E292
BS05	CA	A	D56 E57 E61 E104	D56 E57 E61 E104
BS06	0X9	A	H69 E72 R129 N146 R147 H204 Q211 A251 Y255 T257 E277	H69 E72 R129 N146 R147 H204 Q211 A251 Y255 T257 E277
BS07	CA	A	D51 E59 N101	D51 E59 N101

Gene Ontology

Molecular Function

• GO:0004181 metallocarboxypeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6f79, PDBe:6f79, PDBj:6f79
• PDBsum: 6f79
• UniProt: P29068|CBPT_THEVU Carboxypeptidase T (Gene Name=cpt)