Structure of PDB 6f76 Chain A

Receptor sequence
>6f76A (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
AFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVI
DGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHY
REQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSA
KTRQGVDDAFYTLVREIRKHKE
3D structure
PDB6f76 BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S17 T35 S21 T39
BS02 GNP A G13 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N116 K117 D119 S145 A146 G17 G19 K20 S21 A22 F32 V33 D34 Y36 P38 T39 G64 N120 K121 D123 S149 A150
BS03 CVK A K5 V7 S39 Y40 R41 D54 L56 Y71 T74 K9 V11 S43 Y44 R45 D58 L60 Y75 T78
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:6f76, PDBe:6f76, PDBj:6f76
PDBsum6f76
PubMed29989546
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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