Structure of PDB 6f6u Chain A

Receptor sequence
>6f6uA (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLK
TFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEA
VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHH
LAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADL
KTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWT
DRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWET
WADLVHPDAQDILDTLEDNREWYQSTIP
3D structure
PDB6f6u Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
ChainA
Resolution1.828 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H330 H366 D367 D484 H81 H117 D118 D235
BS02 CV8 A Y325 S374 M439 T499 I502 F506 Q535 F538 Y76 S125 M190 T250 I253 F257 Q286 F289 MOAD: ic50=16uM
PDBbind-CN: -logKd/Ki=4.80,IC50=16uM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6f6u, PDBe:6f6u, PDBj:6f6u
PDBsum6f6u
PubMed29652483
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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