Structure of PDB 6f6r Chain A

Receptor sequence
>6f6rA (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
QDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALI
ICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA
FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT
KNCPSLKDKPKVIIIQACRGDSPGVVWFKD
3D structure
PDB6f6r Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CVE A R179 Q283 C285 R62 Q166 C168 PDBbind-CN: -logKd/Ki=8.25,IC50=5.6nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6f6r, PDBe:6f6r, PDBj:6f6r
PDBsum6f6r
PubMed29648825
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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