Structure of PDB 6f58 Chain A

Receptor sequence
>6f58A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
GELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYS
FLLDFVAADNHRWKYVNGEWVPGAPSCVYIHPDSPNFGAHWMKAPVSFSK
VKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAV
TAYQNEEITALKIKYNPFAKAFLDAKERSH
3D structure
PDB6f58 Crystal structure of human Brachyury (T) in complex with DNA
ChainA
Resolution2.253 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K66 N150 S162 T196 P212 F213 A216 K27 N105 S117 T151 P167 F168 A171
BS02 dna A R69 R70 K147 Y198 T204 N211 F213 F217 R30 R31 K102 Y153 T159 N166 F168 F172
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6f58, PDBe:6f58, PDBj:6f58
PDBsum6f58
PubMed
UniProtO15178|TBXT_HUMAN T-box transcription factor T (Gene Name=TBXT)

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