Structure of PDB 6f57 Chain A

Receptor sequence

>6f57A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]

AEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRH
QGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNP
VMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKF
SKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDV
SNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV

3D structure

PDB

6f57 Structural basis for DNMT3A-mediated de novo DNA methylation.

Chain

Resolution

3.098 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I715 P718 V763 R836 N838 R882 L883	I88 P91 V136 R209 N211 R255 L256
BS02	dna	A	S708 C710 N711 S714 I715 V716 N717 P718 E756 V758 R792 R831 T832 T834 T835 R836 K844 G890	S81 C83 N84 S87 I88 V89 N90 P91 E129 V131 R165 R204 T205 T207 T208 R209 K217 G263
BS03	SAH	A	F640 D641 G642 I643 T645 E664 D686 V687 G707 L730 R891 S892 W893	F13 D14 G15 I16 T18 E37 D59 V60 G80 L103 R264 S265 W266	BindingDB: IC50=>50000nM

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:6f57, PDBe:6f57, PDBj:6f57
PDBsum	6f57
PubMed	29414941
UniProt	Q9Y6K1\|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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