Structure of PDB 6f44 Chain A

Receptor sequence
>6f44A (length=1399) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPKPIRGFCQRLKGKQGRFRGNLSG
KRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELI
VNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGD
VVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLH
VPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSF
YDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNS
PVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLG
DGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPA
DDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLL
SKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISG
NRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGRE
GLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDG
LDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPL
EERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALA
NLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKF
LEIALFKYRKARLEPGTAIGAIGAQSIGEPMNVTLGVPRIKEIINASKVI
STPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQV
RIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFP
SENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLR
DVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVD
PRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAF
YMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFES
3D structure
PDB6f44 Molecular mechanism of promoter opening by RNA polymerase III.
ChainA
Resolution4.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C70 H80 C69 H79
BS02 ZN A C107 S111 A112 C106 S110 A111
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6f44, PDBe:6f44, PDBj:6f44
PDBsum6f44
PubMed29345638
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

[Back to BioLiP]