Structure of PDB 6f40 Chain A

Receptor sequence
>6f40A (length=1398) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPKPIRGFCQRLKGKQGRFRGNLSG
KRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELI
VNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGD
VVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLH
VPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSF
YDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNS
PVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLG
DGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPA
DDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLL
SKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISG
NRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGRE
GLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDG
LDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPL
EERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALA
NLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKF
LEIALFKYRKARLEPGTAIGAIGAQSIGEPMNVTLGVPRIKEIINASKVI
STPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQV
RIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFP
ENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRD
VMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDP
RHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFY
MKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFES
3D structure
PDB6f40 Molecular mechanism of promoter opening by RNA polymerase III.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A V186 R1373 E1390 V179 R1321 E1338
BS02 ZN A T69 C70 H80 T68 C69 H79
BS03 ZN A C107 C110 C154 C106 C109 C153
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6f40, PDBe:6f40, PDBj:6f40
PDBsum6f40
PubMed29345638
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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