Structure of PDB 6f3f Chain A

Receptor sequence
>6f3fA (length=449) Species: 10090 (Mus musculus) [Search protein sequence]
RMVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTG
YIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY
SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGE
VWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS
EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM
NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA
PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP
3D structure
PDB6f3f A switch in nucleotide affinity governs activation of the Src and Tec family kinases.
ChainA
Resolution2.41796 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 A390 N391 D404
Catalytic site (residue number reindexed from 1) D306 A310 N311 D324
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L273 V281 A293 K295 Y340 M341 A390 L393 L193 V201 A213 K215 Y260 M261 A310 L313 PDBbind-CN: -logKd/Ki=4.52,Ki=30uM
BS02 MG A N391 D404 N311 D324
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6f3f, PDBe:6f3f, PDBj:6f3f
PDBsum6f3f
PubMed29234112
UniProtP05480|SRC_MOUSE Proto-oncogene tyrosine-protein kinase Src (Gene Name=Src)

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