Structure of PDB 6f33 Chain A

Receptor sequence
>6f33A (length=719) Species: 10116 (Rattus norvegicus) [Search protein sequence]
WVTEACAPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGL
HSKYMRAVYPTKAFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSV
EKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNS
VPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKAL
QLVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPE
INFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPD
LPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGCEGGTHGYNNEFKSMEAIF
LAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKAP
FYQPSHAEELSKSACGFTTPLPKDSLNCSCLAQEEQVNQRLNLNRGEVSA
TEKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSYTVPKPG
DTSSLPPTVPDCLRADVRVDPSESQKCSFYLADQNIDHGFLYPPAIKGNN
ESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGPIFD
YNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPGWLD
VLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLDFYQ
EKTQPVSEILQLKTYLPTF
3D structure
PDB6f33 Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZAN A A206 F207 N227 L240 W272 P273 Y290 Y321 D326 H330 H483 A63 F64 N84 L97 W129 P130 Y147 Y178 D183 H187 H337
BS02 ZN A D168 A206 D373 H374 D25 A63 D230 H231
BS03 ZN A D326 H330 H483 D183 H187 H337
BS04 CA A D752 N754 D756 H758 D760 D600 N602 D604 H606 D608
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f33, PDBe:6f33, PDBj:6f33
PDBsum6f33
PubMed30022031
UniProtP97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Gene Name=Enpp3)

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