Structure of PDB 6f2t Chain A

Receptor sequence
>6f2tA (length=710) Species: 10116 (Rattus norvegicus) [Search protein sequence]
WVTEACAPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGL
HSKYMRAVYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSV
EKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNS
VPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKAL
QLVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPE
INFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPD
LPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGNCEGGTHGYNNEFKSMEAI
FLAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKA
PFYQPSHAEELSKSAGCGFTTPLPKDSLNCSCLAQVNQRLNLNRGEVSAT
EKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSYTVPKPGP
PTVPDCLRADVRVDPSESQKCSFYLAIDHGFLYPPAIKGNNESQYDALIT
SNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGPIFDYNYDGHFDA
PDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPGWLDVLPFVVPHR
PTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLDFYQEKTQPVSEI
LQLKTYLPTF
3D structure
PDB6f2t Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A T206 D326 H483 T63 D183 H338
BS02 ZN A D168 T206 D373 H374 D25 T63 D230 H231
BS03 ZN A D326 H330 H483 D183 H187 H338
BS04 CA A D752 N754 D756 H758 D760 D591 N593 D595 H597 D599
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f2t, PDBe:6f2t, PDBj:6f2t
PDBsum6f2t
PubMed30022031
UniProtP97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Gene Name=Enpp3)

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