Structure of PDB 6f26 Chain A

Receptor sequence
>6f26A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIGDIYLGTDIAAGEEVAIKLECVLHIESKIYKMMQGGV
GIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMI
SRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQ
HIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW
QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDK
PDYSYLRQLFRNLFHRQGFSYDYVFDWNML
3D structure
PDB6f26 Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.
ChainA
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C9Z A I15 I23 A36 K38 M80 M82 L85 D91 L135 I13 I16 A29 K31 M67 M69 L72 D78 L122 MOAD: ic50=0.024uM
PDBbind-CN: -logKd/Ki=7.62,IC50=24nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6f26, PDBe:6f26, PDBj:6f26
PDBsum6f26
PubMed30832206
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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