Structure of PDB 6ezm Chain A

Receptor sequence
>6ezmA (length=212) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKAEQATQSQVINVHT
GIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEA
LGAVRGVKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSC
EMIPHFLESFAEASRITLHVDCLRGKNDHHRSESAFKALAVAIREATSPN
GTNDVPSTKGVL
3D structure
PDB6ezm Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H64 H186 E190 H57 H179 E183
BS02 5LD A H64 H186 H187 E190 K194 H57 H179 H180 E183 K187
BS03 MN A H90 E94 H162 H83 E87 H155
BS04 5LD A H90 H91 E94 H83 H84 E87
BS05 5LD A S214 K216 S207 K209
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ezm, PDBe:6ezm, PDBj:6ezm
PDBsum6ezm
PubMed29434040
UniProtP06633|HIS7_YEAST Imidazoleglycerol-phosphate dehydratase (Gene Name=HIS3)

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