Structure of PDB 6eyz Chain A

Receptor sequence
>6eyzA (length=862) Species: 10090 (Mus musculus) [Search protein sequence]
DRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQ
LGWVEWLQYSFPLQLEPSARGNRALLVNVKFEGSEESFTFQVSTKDMPLA
LMACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQYICSC
LHSGLTPHLTMVHSSSILAMRDEQSNPASLWSLEQPFSIELIEGRKVNAD
ERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPR
MARLCFALYAVVDCPIAWANLMLFDYKDQLKTGERCLYMWPSVLLNPAGT
VRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERRITEEEQL
QLREILERGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVA
QMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYL
LQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVAL
RFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTK
EMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIM
YSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTP
YGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSK
NPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF
GHFLGNRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRH
GLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVN
3D structure
PDB6eyz Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5W A M752 W760 I777 K779 D787 I825 V827 V828 M900 D911 M590 W598 I615 K617 D625 I663 V665 V666 M738 D749 PDBbind-CN: -logKd/Ki=8.10,IC50=7.94nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6eyz, PDBe:6eyz, PDBj:6eyz
PDBsum6eyz
PubMed29232121
UniProtO35904|PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Gene Name=Pik3cd)

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