Structure of PDB 6exw Chain A

Receptor sequence
>6exwA (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCC
DGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLE
3D structure
PDB6exw Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C327 C47 C50 H67 C74
BS02 C3K A R308 C309 R55 C56
BS03 C3K A D297 G306 L307 R308 C309 W310 E311 D314 E319 W323 D44 G53 L54 R55 C56 W57 E58 D61 E66 W70
External links
PDB RCSB:6exw, PDBe:6exw, PDBj:6exw
PDBsum6exw
PubMed30055105
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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