Structure of PDB 6ewz Chain A

Receptor sequence
>6ewzA (length=202) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DEAFDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERR
VKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEML
LKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIR
TIGMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEI
TE
3D structure
PDB6ewz Structural basis for (p)ppGpp synthesis by theStaphylococcus aureussmall alarmone synthetase RelP.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A K88 K92 K138 K140 Y142 K147 N149 Y151 H155 Q176 A186 E189 K60 K64 K110 K112 Y114 K119 N121 Y123 H127 Q148 A158 E161
BS02 APC A R78 K80 S84 K88 R91 D107 G110 I111 R112 E174 Q176 R50 K52 S56 K60 R63 D79 G82 I83 R84 E146 Q148
Gene Ontology
Molecular Function
GO:0008728 GTP diphosphokinase activity
GO:0016301 kinase activity
Biological Process
GO:0015969 guanosine tetraphosphate metabolic process
GO:0015970 guanosine tetraphosphate biosynthetic process
GO:0016310 phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ewz, PDBe:6ewz, PDBj:6ewz
PDBsum6ewz
PubMed29326162
UniProtW8U368

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