Structure of PDB 6ev0 Chain A

Receptor sequence
>6ev0A (length=230) Species: 169963 (Listeria monocytogenes EGD-e) [Search protein sequence]
NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSI
SENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINE
LKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILT
YVYGKETPDGIKITLDNLTMQELGYSSAVSRIISKLKQEKVIVYKNSCFY
VQNLDYLKRYAPKLDEWFYLACPATWGKLN
3D structure
PDB6ev0 Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BYK A Q61 Y62 Y63 K64 F67 Y126 I149 C229 Q60 Y61 Y62 K63 F66 Y125 I148 C222 MOAD: ic50=1.8uM
PDBbind-CN: -logKd/Ki=5.74,IC50=1.8uM
BS02 C8N A L60 K130 F131 L59 K129 F130
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6ev0, PDBe:6ev0, PDBj:6ev0
PDBsum6ev0
PubMed29667825
UniProtP22262|PRFA_LISMO Listeriolysin regulatory protein (Gene Name=prfA)

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