Structure of PDB 6eu6 Chain A

Receptor sequence
>6eu6A (length=405) Species: 174633 (Candidatus Kuenenia stuttgartiensis) [Search protein sequence]
MENIQININHLWVIMAACMVFLMQLGFTSYETGFSQSKNAISIALRNLVD
TLISSLVFFSVGFGFMFGKSYMGLIGIDLFFANDLALHPNTLSYSFFFFQ
MVFASTAATILTGAIAERSGFIPNIAGTAFIVAIIYPIFGHWAWGNLFSP
DQTGWLKELGFIDFAGATVVHSIGGWFAMAAAIMVGPRIDKYNPDGSSNR
IGLHNVPLATLGTFFLWFGWFGFNGGSLLRVSVNIGLVILNTNMAAASAG
VSALIFIYATRKRIEAGSLFTAILAGLVAITASSNMVTPVSAVAIGLITG
ILAIIAEGFIEKTLKIDDPVSAIAVHGVGGVIGTLCVAIFAQKSYLLAEN
GSRMHQLGIQALGVIVAFSWSFGLGMLFFLCLKKVKRLRVTPEEEKRGLN
VAEAA
3D structure
PDB6eu6 Signaling ammonium across membranes through an ammonium sensor histidine kinase.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZDM A P187 L314 K315 P187 L314 K315 PDBbind-CN: -logKd/Ki=4.39,Kd=41uM
BS02 NH4 A Q24 N47 D50 T51 Q24 N47 D50 T51
BS03 NH4 A E31 N47 T109 T112 E31 N47 T109 T112
Gene Ontology
Molecular Function
GO:0008519 ammonium channel activity
Biological Process
GO:0072488 ammonium transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eu6, PDBe:6eu6, PDBj:6eu6
PDBsum6eu6
PubMed29323112
UniProtQ1Q357

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