Structure of PDB 6eu3 Chain A

Receptor sequence
>6eu3A (length=1402) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSGNLSGKRVDFSGRTVISPDPNLSIDEVA
VPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRN
LRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIR
PWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLT
PKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIP
PPAIMKPYYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPN
EMSQNDGFVIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANA
MNRMAKLCARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELIT
LFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLI
MATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQ
SKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSL
EDLSCQYDNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAY
NITFNNQDKGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAE
YVDQYDAERDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGID
PDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIG
AQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINA
VLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTI
DKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPSENDVFY
RMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDG
VIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLL
GDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAV
EGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALK
AN
3D structure
PDB6eu3 Structural basis of RNA polymerase III transcription initiation.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C67 C77 H80 C66 C76 H79
BS02 ZN A C107 C154 C106 C153
BS03 MG A D511 D513 D515 D468 D470 D472
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eu3, PDBe:6eu3, PDBj:6eu3
PDBsum6eu3
PubMed29345637
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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