Structure of PDB 6es9 Chain A

Receptor sequence

>6es9A (length=545) Species: 318586 (Paracoccus denitrificans PD1222)

MPADTPSALLALAGEALPELESLQSRATEALRALVAPAGKPQPALLEQHQ
HAAHALSWLTTYVESIRQLSGWAGRLAEAGNLGRIEALILQIGLGEYLGQ
IAGGIPMSQTEFARLSDLELDWQPGEAAAKLMRGNTAPARAELARLMQDN
HGRATFGATGLDEDLEMIRDQFRRYAEERVIPNAHEWHLKDQLIPMEIIE
ELAELGVFGLTIPEEFGGLGLSKASMVVVTEELSRGYIGVGSLGTRSEIA
AELILCGGTEAQKAKWLPGLASGEILSTAVFTEPNTGSDLGSLRTRAVRD
GEDWVVTGNKTWITHAQRTHVMTLLARTDPETTDWRGLSMFLAEKEPGTD
DDPFPTPGMTGGEIEVLGYRGMKEYELGFDGFRIKGENLLGGEPGRGFKQ
LMETFESARIQTAARAVGVAQSAAEIGMRYAVDRKQFGKSLIEFPRVADK
LAMMAVEIMIARQLTYFSAWEKDHGRRCDLEAGMAKLLGARVAWAAADNA
LQIHGGNGFALEYAISRVLCDARILNIFEGAAEIQAQVIARRLLD

3D structure

• PDB: 6es9 Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family.
• Chain: A
• Resolution: 1.37 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): F287 T288 A414 R547
• Catalytic site (residue number reindexed from 1): F281 T282 A408 R541
• Enzyme Commision number: 1.3.8.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	A	R81 F473 W476	R75 F467 W470
BS02	FAD	A	Q56 A285 F287 T288 G293 S294 W318 I319 T320 E380 F534 A537 E539 I540	Q50 A279 F281 T282 G287 S288 W312 I313 T314 E374 F528 A531 E533 I534
BS03	FAD	A	R440 Q442 F443 L447 F450 Q508 I509 G511 G512	R434 Q436 F437 L441 F444 Q502 I503 G505 G506

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003995 acyl-CoA dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
• GO:0050660 flavin adenine dinucleotide binding

External links

• PDB: RCSB:6es9, PDBe:6es9, PDBj:6es9
• PDBsum: 6es9
• PubMed: 29275330
• UniProt: A1B5Y0