Structure of PDB 6es0 Chain A

Receptor sequence
>6es0A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTP
LLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLN
ELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILL
DNEFHVKIADFGLSKWGTIIYMPPENYASIKHDIYSYAVITWEVLSRKQP
FEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPD
ERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQS
3D structure
PDB6es0 Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors.
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D142 Q146 N147 D160
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BW8 A R26 A45 K47 E66 L70 L79 T95 Y97 M98 H144 L153 A163 D164 F165 W170 R22 A41 K43 E62 L66 L75 T91 Y93 M94 H140 L149 A159 D160 F161 W166 MOAD: ic50=2.26uM
PDBbind-CN: -logKd/Ki=5.65,IC50=2.26uM
BindingDB: IC50=4870nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6es0, PDBe:6es0, PDBj:6es0
PDBsum6es0
PubMed29409752
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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