Structure of PDB 6erh Chain A

Receptor sequence
>6erhA (length=490) Species: 9606 (Homo sapiens) [Search protein sequence]
GRDSLIFLVDASKAMFESDELTPFDMSIQCIQSVYISKIISSDRDLLAVV
FYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMG
HGSDYSLSEVLWVCANLFSDSHKRIMLFTNEDNPHGNDSAKASRARTKAG
DLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDRVHFEESSKLEDLLR
KVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNE
PVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPG
LMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEV
AALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKR
KMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALA
LDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDY
3D structure
PDB6erh XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R254 A255 L256 S257 R258 R403 R444 R210 A211 L212 S213 R214 R359 R400
BS02 dna A R80 N275 Q278 R363 R403 R44 N231 Q234 R319 R359
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6erh, PDBe:6erh, PDBj:6erh
PDBsum6erh
PubMed30291363
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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