Structure of PDB 6enx Chain A

Receptor sequence
>6enxA (length=267) Species: 7955 (Danio rerio) [Search protein sequence]
PSSDLTAFREHFAKAKHIAIITGAGVSAESGVPTFRGPGGFWRKWQAQDL
ATPEAFSRDPSLVWEFYHYRREVMRSKMPNPAHLAIAECEARLGQQGRSV
VIITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCGEVKANHKSPICPALD
GKGAPDPNTKEARIPVELLPRCERKSCNGLLRPHVVWFGETLDSDILTAV
ERELEKCDLCLVVGTSSIVYPAAMFAPQVASRGVPVAEFNMECTPATQRF
KYHFEGPCGSTLPPALE
3D structure
PDB6enx Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P64 T65 F66 R67 N137 D139 H154
Catalytic site (residue number reindexed from 1) P33 T34 F35 R36 N106 D108 H123
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C162 C165 C203 C208 C131 C134 C172 C177
BS02 BJW A G54 A55 G56 F66 R67 Y98 R101 Q136 I138 H154 V217 W218 F219 G220 E221 T222 G245 T246 S247 V250 Y251 N271 M272 P288 C289 G23 A24 G25 F35 R36 Y67 R70 Q105 I107 H123 V186 W187 F188 G189 E190 T191 G214 T215 S216 V219 Y220 N240 M241 P257 C258 PDBbind-CN: -logKd/Ki=6.08,IC50=0.83uM
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6enx, PDBe:6enx, PDBj:6enx
PDBsum6enx
PubMed29044784
UniProtQ6DHI5|SIR5_DANRE NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=sirt5)

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