Structure of PDB 6el6 Chain A

Receptor sequence
>6el6A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB6el6 Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 R585 M593 Q597 E751 M752 E755 N759 V46 K50 R56 M64 Q68 E222 M223 E226 N230
BS02 B9Q A M560 L563 N564 L566 G567 Q570 M601 M604 A607 L608 R611 F623 Q642 M646 Y735 C736 T739 M31 L34 N35 L37 G38 Q41 M72 M75 A78 L79 R82 F94 Q113 M117 Y206 C207 T210 MOAD: ic50=6.3nM
BindingDB: IC50=2.8nM,EC50=1.3nM
External links
PDB RCSB:6el6, PDBe:6el6, PDBj:6el6
PDBsum6el6
PubMed29424542
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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