Structure of PDB 6ej7 Chain A

Receptor sequence
>6ej7A (length=706) Species: 9606 (Homo sapiens) [Search protein sequence]
DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFC
PLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYH
KDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTY
LQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSH
GRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRR
FVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLR
ITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFE
AVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTL
YHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIK
HHATNLAVSKLETLETWVMPKKVFKIASPDFGRLQFSEVGTDWDAKERLF
RNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTA
EFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPE
EALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALE
GWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVK
PDGRLR
3D structure
PDB6ej7 Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.26: protein xylosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H451 K461 Q462 R466 R477 E529 W555 R557 W571 C572 G573 C574 H200 K210 Q211 R215 R226 E278 W304 R306 W320 C321 G322 C323
BS02 UDX A V333 V334 H335 T390 W392 D494 W495 S575 R598 K599 V82 V83 H84 T139 W141 D243 W244 S324 R347 K348
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0030158 protein xylosyltransferase activity
Biological Process
GO:0030166 proteoglycan biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ej7, PDBe:6ej7, PDBj:6ej7
PDBsum6ej7
PubMed29681470
UniProtQ86Y38|XYLT1_HUMAN Xylosyltransferase 1 (Gene Name=XYLT1)

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