Structure of PDB 6ej0 Chain A

Receptor sequence
>6ej0A (length=453) Species: 9606 (Homo sapiens) [Search protein sequence]
MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPF
ACDVDKLHFTPRIQRLNELEAQTRRDYTLRTFGEMADAFKSDYFNMPVHM
VPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGIKLSPEE
EEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIE
DHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQ
LVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVN
FCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTV
QKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFM
SAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLR
AES
3D structure
PDB6ej0 Crystal structure of KDM5B in complex with KDOPZ000049a.
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C692 C695 C715 H718 C391 C394 C414 H417
BS02 MN A L90 N91 L413 V414 T416 E419 L66 N67 L113 V114 T116 E119
BS03 MN A H499 E501 H587 H198 E200 H286
BS04 B7K A R86 R98 Y425 W486 Y488 S495 F496 H499 K517 H587 R62 R74 Y125 W185 Y187 S194 F195 H198 K216 H286
External links
PDB RCSB:6ej0, PDBe:6ej0, PDBj:6ej0
PDBsum6ej0
PubMed
UniProtQ9UGL1|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)

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