Structure of PDB 6eiy Chain A

Receptor sequence
>6eiyA (length=456) Species: 9606 (Homo sapiens) [Search protein sequence]
MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPF
ACDVDKLHFTPRIQRLNELEAQTRVKARDYTLRTFGEMADAFKSDYFNMP
VHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGIKLS
PEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCW
HIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDL
LHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAE
AVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVA
STVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTT
CFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNAL
KLRAES
3D structure
PDB6eiy Crystal structure of KDM5B in complex with KDOPZ000034a.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C692 C695 C715 H718 C394 C397 C417 H420
BS02 MN A L90 N91 L413 V414 T416 E419 L66 N67 L116 V117 T119 E122
BS03 MN A H499 E501 H587 H201 E203 H289
BS04 B6W A R98 Y425 Y488 S495 F496 H499 K517 H587 R74 Y128 Y190 S197 F198 H201 K219 H289
External links
PDB RCSB:6eiy, PDBe:6eiy, PDBj:6eiy
PDBsum6eiy
PubMed
UniProtQ9UGL1|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)

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