Structure of PDB 6ein Chain A

Receptor sequence
>6einA (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPF
ACDVDKLHFTPRIQRLNELEAARDYTLRTFGEMADAFKSDYFNMPVHMVP
TELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDKLSPEEEEYL
DSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWS
YSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELLVTIMNPNTLMTHE
VPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCV
EHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKAL
RETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVC
LHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAES
3D structure
PDB6ein Crystal structure of KDM5B in complex with S49365a.
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G481 Y488 H499 E501 H587 A599
Catalytic site (residue number reindexed from 1) G176 Y183 H194 E196 H272 A284
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7Z A Y425 D428 C480 Y488 F496 H499 E501 K517 W519 H587 Y123 D126 C175 Y183 F191 H194 E196 K212 W214 H272
BS02 ZN A C692 C695 C715 H718 C377 C380 C400 H403
BS03 MN A H499 E501 H587 H194 E196 H272
External links
PDB RCSB:6ein, PDBe:6ein, PDBj:6ein
PDBsum6ein
PubMed
UniProtQ9UGL1|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)

[Back to BioLiP]