Structure of PDB 6egs Chain A

Receptor sequence
>6egsA (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]
AEAKVRWPDFNQEAYVGGQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPA
TSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALL
GKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPL
LERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTP
EQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLE
ISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPVFARNTRRAAEVWMDEY
KNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDH
QDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKH
MDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDS
RTAKSGGLSVEVCGPALSQQWKFTLNLQ
3D structure
PDB6egs Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D224 H226 H359 D137 H139 H272
BS02 UD2 A T143 D176 R201 L204 D224 H226 G308 G309 V330 G332 E334 N335 H359 H365 T56 D89 R114 L117 D137 H139 G221 G222 V243 G245 E247 N248 H272 H278 PDBbind-CN: -logKd/Ki=3.59,Kd=260uM
External links
PDB RCSB:6egs, PDBe:6egs, PDBj:6egs
PDBsum6egs
PubMed29601100
UniProtQ10471|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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