Structure of PDB 6ege Chain A

Receptor sequence
>6egeA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKK
LALKQQFDQEIKVMAKCQHENLVELLGFSLCLVYVYMPNGSLLDRLSCLD
GTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKIS
DFGLARARIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDE
HREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHE
KKNKRPDIKKVQQLLQEMTA
3D structure
PDB6ege Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
ChainA
Resolution1.401 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) N133 K135 A137 N138 D151 T162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DL1 A M192 A211 Y262 Y264 M265 G268 L318 S328 D329 M28 A47 Y84 Y86 M87 G90 L140 S150 D151
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6ege, PDBe:6ege, PDBj:6ege
PDBsum6ege
PubMed30679311
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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