Structure of PDB 6eet Chain A

Receptor sequence

>6eetA (length=443) Species: 10090 (Mus musculus)

NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGMPASRVRYRVDD
VQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMSSS
ATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVY
SIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANL
RVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFASVLRVKAT
DRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK
FQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTE
ILDRYVQEQIPGAKVVVESIGARRHGDAYSLEDYSKCDLTVYAIDPQTNR
AIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTS

3D structure

• PDB: 6eet Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
• Chain: A
• Resolution: 3.23 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	A	R945 S996	R47 S98
BS02	MAN	A	R908 Q950 T1000	R10 Q52 T102
BS03	MAN	A	D947 Q950 S998	D49 Q52 S100
BS04	CA	A	E1026 E1077 D1115 E1116 D1118 D1151	E128 E179 D217 E218 D220 D253
BS05	CA	A	N1117 H1119 D1149 D1151 Y1155 D1205	N219 H221 D251 D253 Y257 D307
BS06	CA	A	E1026 D1075 E1077 D1118	E128 D177 E179 D220
BS07	CA	A	N899 Y901 D931 D933 A939 D989	N1 Y3 D33 D35 A41 D91

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0098609 cell-cell adhesion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6eet, PDBe:6eet, PDBj:6eet
• PDBsum: 6eet
• PubMed: 32963095
• UniProt: Q99PJ1|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)