Structure of PDB 6edz Chain A

Receptor sequence
>6edzA (length=733) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAR
EAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATS
AKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQ
RAATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG
TKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLI
DSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYAL
GDSEYAAAGGWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVAA
WEDDAGLMTYGEAVADVLEAPEEWRAFAARASLHAARAKAKELGADPPWD
CELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFA
EAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFIT
YGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGP
RSDAALAASSGRTATTKALVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQL
RPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAE
LRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQ
EVGEIIVAEVNHPRIAELLTPDRVALRKLITKE
3D structure
PDB6edz Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.
ChainA
Resolution2.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y104 D123 D177 D179 H204 E206 C215 H217 R252 E459 Q482 S489 S491
Catalytic site (residue number reindexed from 1) Y93 D112 D166 D168 H193 E195 C204 H206 R241 E437 Q460 S467 S469
Enzyme Commision number 4.1.3.1: isocitrate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A D675 Q676 N677 T678 R684 Q685 R687 M689 T690 T711 D713 N714 Y716 K720 H724 K764 D643 Q644 N645 T646 R652 Q653 R655 M657 T658 T679 D681 N682 Y684 K688 H692 K732
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0019752 carboxylic acid metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6edz, PDBe:6edz, PDBj:6edz
PDBsum6edz
PubMed31604954
UniProtQ8VJU4|ACEA2_MYCTO Isocitrate lyase 2 (Gene Name=icl2)

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