Structure of PDB 6edw Chain A

Receptor sequence
>6edwA (length=742) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAR
EAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATS
AKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQ
RAATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG
TKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLI
DSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYAL
GDSEYAAAGGWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVAA
WEDDAGLMTYGEAVADVLEFGMAPEEWRAFAARASLHAARAKAKELGADP
PWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADAR
QFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFN
FITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLV
GGPRSDAALAASSGRTATTKAMSTQHQHLVQTEVPRKLLEEWLAMWSGHY
QLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILL
VRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMK
SHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITK
3D structure
PDB6edw Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y104 D123 D177 D179 H204 E206 C215 H217 R252 E459 Q482 S489 S491
Catalytic site (residue number reindexed from 1) Y93 D112 D166 D168 H193 E195 C204 H206 R241 E440 Q463 S470 S472
Enzyme Commision number 4.1.3.1: isocitrate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A A450 A453 Q482 A431 A434 Q463
BS02 MG A D177 D179 D166 D168
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6edw, PDBe:6edw, PDBj:6edw
PDBsum6edw
PubMed31604954
UniProtQ8VJU4|ACEA2_MYCTO Isocitrate lyase 2 (Gene Name=icl2)

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