Structure of PDB 6edl Chain A

Receptor sequence
>6edlA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
NPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGEVYEGQVSSPLQVAVKT
LPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAG
GDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIA
ARNCLLTCPGPGRVAKIGDFCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV
LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQ
HQPEDRPNFAIILERIEYCTQDPDVINTALPI
3D structure
PDB6edl Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
ChainA
Resolution2.799 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1249 R1253 N1254 D1270
Catalytic site (residue number reindexed from 1) D148 R152 N153 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J4M A A1148 M1199 G1202 N1254 L1256 G1269 A47 M98 G101 N153 L155 G168 PDBbind-CN: -logKd/Ki=8.70,IC50=2.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6edl, PDBe:6edl, PDBj:6edl
PDBsum6edl
PubMed31009559
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

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