Structure of PDB 6edb Chain A

Receptor sequence
>6edbA (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
KLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGS
YYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLS
QFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLIS
EKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKH
AKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLM
KYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLC
FDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERN
NEFPVFD
3D structure
PDB6edb Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
ChainA
Resolution3.209 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K173 L174 R176 E398 K10 L11 R13 E235
BS02 dna A R176 Y214 Y215 K400 R13 Y51 Y52 K237
BS03 ZN A H390 C397 C404 H227 C234 C241
External links
PDB RCSB:6edb, PDBe:6edb, PDBj:6edb
PDBsum6edb
PubMed31142647
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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