Structure of PDB 6ed7 Chain A

Receptor sequence

>6ed7A (length=429) Species: 562 (Escherichia coli)

ATTDDLAFDQRHIWHPYTSMTSPLPVYPVVSAEGCELILSDGRRLVDGMS
SWWAAIHGYNHPQLNAAMKSQIDAMSHVMFGGITHAPAIELCRKLVAMTP
QPLECVFLADSGSVAVEVAMKMALQYWQAKGEARQRFLTFRNGYHGDTFG
AMSVCDPDNSMHSLWKGYLPENLFAPAPQSRMDGEWDERDMVGFARLMAA
HRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKICDREGILLIADEIATG
FGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTTREVAETISNGE
AGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQLREQLAPA
RDAEMVADVRVLGAIGVVETTHPVNMAALQKFFVEQGVWIRPFGKLIYLM
PPYIILPQQLQRLTAAVNRAVQDETFFCQ

3D structure

• PDB: 6ed7 Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772
• Chain: A
• Resolution: 2.43 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y17 Y144 D245 K274
• Catalytic site (residue number reindexed from 1): Y17 Y144 D245 K274
• Enzyme Commision number: 2.6.1.62: adenosylmethionine--8-amino-7-oxononanoate transaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	G112 S113 Y144 H145 D245 I247 K274	G112 S113 Y144 H145 D245 I247 K274
BS02	J4J	A	W52 Y144 A217 K274 F393	W52 Y144 A217 K274 F393
BS03	J4J	A	Y17 W52 D147 R391 F393	Y17 W52 D147 R391 F393

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity
• GO:0008483 transaminase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0042803 protein homodimerization activity

Biological Process

• GO:0009102 biotin biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6ed7, PDBe:6ed7, PDBj:6ed7
• PDBsum: 6ed7
• UniProt: P12995|BIOA_ECOLI Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (Gene Name=bioA)