Structure of PDB 6eb1 Chain A

Receptor sequence
>6eb1A (length=135) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGISMNKELKKIIGQVR
DQAEHLKTAVQMAVFIHNHKRYSAGERIVDIIATD
3D structure
PDB6eb1 An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J3M A Q95 L102 T124 T125 A129 W132 Q40 L47 T69 T70 A74 W77 MOAD: ic50=4.65uM
PDBbind-CN: -logKd/Ki=5.33,IC50=4.65uM
BindingDB: IC50=4650nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6eb1, PDBe:6eb1, PDBj:6eb1
PDBsum6eb1
PubMed30783506
UniProtF2WR52

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