Structure of PDB 6e8q Chain A

Receptor sequence

>6e8qA (length=527) Species: 307796 (Saccharomyces cerevisiae YJM789)

VGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPP
LVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPK
GHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGA
LTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFT
ASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHA
QKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANL
LIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTY
DLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVL
VSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVS
SPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFT
SMVTLPTGPAKIIWEKRNPEQKIGGRH

3D structure

• PDB: 6e8q Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.
• Chain: A
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	Y126 Y140 L147 K151 V311 G315 T318 P379 L383 R385 P462 F463 H468 C470 G472	Y119 Y133 L140 K144 V304 G308 T311 P372 L376 R378 P455 F456 H461 C463 G465
BS02	X2N	A	A69 Y72 G73 Y126 L129 F134 G310 G314 L380 H381 F384 T507 S508 M509	A62 Y65 G66 Y119 L122 F127 G303 G307 L373 H374 F377 T500 S501 M502

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0005506 iron ion binding
• GO:0008168 methyltransferase activity
• GO:0016491 oxidoreductase activity
• GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006696 ergosterol biosynthetic process
• GO:0016126 sterol biosynthetic process
• GO:0032259 methylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6e8q, PDBe:6e8q, PDBj:6e8q
• PDBsum: 6e8q
• PubMed: 30397057
• UniProt: A6ZSR0