Structure of PDB 6e8c Chain A

Receptor sequence

>6e8cA (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]

RGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQI
WFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEK
DRFPGIAAREELARETGLPESRIQIWFQNRRARHP

3D structure

PDB

6e8c Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA.

Chain

Resolution

2.12 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R16 R20 R21 R23 L24 W26 R62 I65 N69 R73 R98 F118 R124 Q139 Q143 R146	R1 R5 R6 R8 L9 W11 R47 I50 N54 R58 R83 F103 R109 Q124 Q128 R131
BS02	dna	A	R20 R23 Y43 Q64 R71 S72 R79 R95 R96 R98 T99 R137 I140 W141 N144 R148	R5 R8 Y28 Q49 R56 S57 R64 R80 R81 R83 T84 R122 I125 W126 N129 R133

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

External links

PDB	RCSB:6e8c, PDBe:6e8c, PDBj:6e8c
PDBsum	6e8c
PubMed	30540931
UniProt	Q9UBX2\|DUX4_HUMAN Double homeobox protein 4 (Gene Name=DUX4)