Structure of PDB 6e7i Chain A

Receptor sequence

>6e7iA (length=494) Species: 9606 (Homo sapiens) [Search protein sequence]

KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHD
QCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILV
DDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLD
SHCECNEHWLEPLLERVAEDRTRVVSPIADVINMDNFQYVGASADLKGGF
DWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGAFVMDKFYFEELGKY
DMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSG
TVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCK
PFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECH
NAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQ
IEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLN

3D structure

PDB

6e7i Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.

Chain

Resolution

1.8 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	G265 A266 S267 F280 W282 W331 R356 F361 R362 K363 Q364 H365	G191 A192 S193 F206 W208 W257 R282 F287 R288 K289 Q290 H291
BS02	UDP	A	T143 F144 D176 R201 G203 L204 D224 S225 H226 V330 W331 H359 R362 Y367	T69 F70 D102 R127 G129 L130 D150 S151 H152 V256 W257 H285 R288 Y293
BS03	MN	A	D224 H226 H359	D150 H152 H285

External links

PDB	RCSB:6e7i, PDBe:6e7i, PDBj:6e7i
PDBsum	6e7i
PubMed	32325029
UniProt	Q10471\|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

[Back to BioLiP]