Structure of PDB 6e6p Chain A

Receptor sequence
>6e6pA (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGDVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSD
DVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFY
TLVREIRQH
3D structure
PDB6e6p Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A D13 G15 K16 S17 A18 F28 V29 N116 K117 D119 S145 D13 G15 K16 S17 A18 F28 V29 N109 K110 D112 S138
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e6p, PDBe:6e6p, PDBj:6e6p
PDBsum6e6p
PubMed31390567
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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