Structure of PDB 6e6j Chain A

Receptor sequence
>6e6jA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
HMEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMD
LSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
FEFRYAKMP
3D structure
PDB6e6j Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
ChainA
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HWV A W370 P371 V376 D377 L381 N429 V435 W25 P26 V31 D32 L36 N84 V90 PDBbind-CN: -logKd/Ki=8.10,IC50=8nM
BindingDB: Ki=4.6nM
External links
PDB RCSB:6e6j, PDBe:6e6j, PDBj:6e6j
PDBsum6e6j
PubMed31969702
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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