Structure of PDB 6e5y Chain A

Receptor sequence

>6e5yA (length=438) Species: 257313 (Bordetella pertussis Tohama I)

TTILPNLPTGQKVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEP
DYDEIPRRAMQYGAEAARLVDCRAQLVAEGIAALQAGAFHISTAGLTYFN
TTPIGRAVTGTMLVAAMKEDGVNIWGDGSTFKGNDIERFYRYGLLTNPDL
KIYKPWLDQTFIDELGGRAEMSEYMRQAGFDYKMSAEKAYSTDSNMLGAT
HEAKDLELLSAGIRIVQPIMGVAFWQDSVQIKAEEVTVRFEEGQPVALNG
VEYADPVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLF
IAYERLVTGIHNEDTIEQYRENGRKLGRLLYQGRWFDPQAIMLRETAQRW
VARAITGEVTLELRRGNDYSLLNTESANLTYAPERLSMEKVENAPFTPAD
RIGQLTMRNLDIVDTREKLFTYVKTGLLAPSALPQIKD

3D structure

• PDB: 6e5y 1.50 Angstrom Resolution Crystal Structure of Argininosuccinate Synthase from Bordetella pertussis in Complex with AMP.
• Chain: A
• Resolution: 1.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D23 R107 D136 S192
• Catalytic site (residue number reindexed from 1): D22 R106 D135 S191
• Enzyme Commision number: 6.3.4.5: argininosuccinate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AMP	A	A17 T42 A43 D194	A16 T41 A42 D193

Gene Ontology

Molecular Function

• GO:0004055 argininosuccinate synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0042803 protein homodimerization activity

Biological Process

• GO:0000050 urea cycle
• GO:0000053 argininosuccinate metabolic process
• GO:0006526 L-arginine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6e5y, PDBe:6e5y, PDBj:6e5y
• PDBsum: 6e5y
• UniProt: Q7VTJ9|ASSY_BORPE Argininosuccinate synthase (Gene Name=argG)