Structure of PDB 6e5l Chain A

Receptor sequence

>6e5lA (length=140) Species: 9606 (Homo sapiens)

PVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMI
IRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGE
KEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQHHHHHH

3D structure

• PDB: 6e5l Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.
• Chain: A
• Resolution: 1.17 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HVD	A	F16 A33 L36 P38 F57 R58 I77	F16 A33 L36 P38 F57 R58 I77	MOAD: Ki=76.3nM PDBbind-CN: -logKd/Ki=7.18,Ki=66.7nM

Gene Ontology

Molecular Function

• GO:0005501 retinoid binding
• GO:0005504 fatty acid binding
• GO:0005515 protein binding
• GO:0008289 lipid binding
• GO:0016918 retinal binding
• GO:0019841 retinol binding
• GO:1904768 all-trans-retinol binding

Biological Process

• GO:0002138 retinoic acid biosynthetic process
• GO:0006776 vitamin A metabolic process
• GO:0015908 fatty acid transport
• GO:0055088 lipid homeostasis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005811 lipid droplet
• GO:0005829 cytosol

External links

• PDB: RCSB:6e5l, PDBe:6e5l, PDBj:6e5l
• PDBsum: 6e5l
• PubMed: 30721022
• UniProt: P09455|RET1_HUMAN Retinol-binding protein 1 (Gene Name=RBP1)